Polarity of T Cell Shape, Motility, and Sensitivity to Antigen
نویسندگان
چکیده
منابع مشابه
Polarity of T cell shape, motility, and sensitivity to antigen.
T cell activation requires contact with APCs. We used optical techniques to demonstrate T cell polarity on the basis of shape, motility, and localized sensitivity to antigen. An intracellular Ca2+ clamp showed that T cell shape and motility are extremely sensitive to changes in [Ca2+]i (Kd = 200 nM), with immobilization and rounding occurring via a calcineurin-independent pathway. Ca2+ dependen...
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ژورنال
عنوان ژورنال: Immunity
سال: 1996
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80409-4